Day 14 :
- Depression | Anxiety Management | Child and Adolescent Psychiatry | Mental Health
Location: Avani Atrium Bangkok
Session Introduction
Joseph Rosado
Medical Director, Medical Cannabis Clinic, USA
Title: PTSD OR Clinical Endocannabinoid Deficiency?
Biography:
Abstract:
Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and disabling depression and anxiety disorder that may develop following exposure to a traumatic event.
Although the use of Medical Cannabis for the treatment of physical and psychological disorders is controversial, medical marijuana is currently legal in Canada, 30 states in the United States and a handful of countries in South America.
Studies published in Molecular Psychiatry and Science Daily showed that treatment using particular compounds found in marijuana may benefit those with PTSD, and that “plant-derived cannabinoids [psychoactive chemicals] such as marijuana may possess some benefits in individuals with PTSD by helping relieve haunting nightmares and other symptoms of PTSD” and As a result of taking medical marijuana, participants reported a decrease in re-experiencing the trauma, less avoidance of situations that reminded them of the trauma, and a decline in hyper-arousal, respectively.
There’s also convincing evidence from multiple studies for reduced endocannabinoid availability in PTSD, i.e., reduced levels of the endocannabinoid anandamide and compensatory increase of CB1 receptor availability in PTSD, and an association between increased CB1 receptor availability in the amygdala and abnormal threat processing, as well as increased severity of hyperarousal, but not dysphoric symptomatology, in trauma survivors.
This presentation will be a literature review supporting the theory of clinical endocannabinoid deficiency and a review on how to treat PTSD with medical cannabis.
Arlinda Cerga Pashoja
London School of Hygiene and Tropical Medicine, London UK
Title: ImplementaLL towards evidence-based tailored implementation strategies for e-Health
Biography:
Arlinda is a mental health researcher with special interest in the development and evaluation of e-health interventions. She is the Co-Deputy Director of the Centre for Global Mental Health in London and works at Imperial College and London School of Hygiene and Tropical Medicine. Arlinda has a background in psychology and has completed a research PhD with the department of Primary Care and Population Health at University College London and an MSc in Mental Health Services Research at the Institute of Psychiatry, Psychology & Neuroscience (Kings College, London). Arlinda has previously held both clinical and research posts with different NHS trusts (South London and Maudsley Foundation Trust; Central and North West London Foundation Trust) in the UK. These posts involved working in a variety of clinical and research settings such as PTSD clinics, Learning Disabilities Teams and Old Age services.
Abstract:
ImplementaLL aims to examine the effectiveness of tailored implementation compared to usual implementation of Internet-based Cognitive Behavioural Therapy (iCBT) in routine practice in twelve implementation sites in nine countries. The ImpleMentAll consortium is made up of 18 partners from Europe and Australia. We will discuss its implementation in two particular countries in the Balkans region i.e.Albania and Kosova.
A stepped-wedge trial (SWT) design will be applied by which the time points at which implementation sites receive the ItFits-toolkit is randomised. By the end of the trial, all implementation sites would have received the ItFits-toolkit sequentially acting as control and intervention condition. There are 6 groups and 2 implementation sites per group. Sites will be informed about the group they are allocated to directly after the first baseline measurement in month 0. Every three months, a new group crosses over from IAU to using the ItFits-toolkit.
There are two types of study participants: 1) implementers, and 2) staff involved in iCBT service delivery. Implementers are directly involved in the development, coordination and execution of implementation activities. Implementers are represented in the study by an Implementation Lead (IL) who has a coordinating role in the implementation activities.
The project has a total duration of 51 months divided in three phases: 1) preparation (Jan 2017 – May 2018), 2) trial period (June 2018 – September 2020), and 3) analysis and reporting (October 2020 – March 2021).
Inderdeep Kaur
Associate Professor, University of Delhi, India
Title: The art of self-management: Chanting meditation
Biography:
Dr Inderdeep Kaur is presently working as an Associate Professor in Botany, SGTB Khalsa College, University of Delhi, Delhi. She has travelled widely and participated in several International conferences. During personal interactions with undergrads over several years she found them stressed due to various reasons. In a bid to help them de-stress she has picked up Stress Management and Traditional Meditation Practices. She was invited to organize a workshop on stress management in Philadelphia Stress Management Summit 2015 and later she held a session in Nursing Global 2017, in Amsterdam. She has also published articles like SLEEP: THE SCIENCE OF MIND AT REST and TRADITIONAL MEDICINES AND THE SAFETY ISSUES. In a bid to spread this therapy of calming the entire system in humans, she would be conducting a session on Meditation at Eurosci 2018 at Paris during 21-22June 2018
Herself, regular at performing these meditative exercises, she has a vision to target the spiritual self of the person for she believes that medication is available for body and to some extent mental ailments but spiritual health needs to be achieved with practices like meditation and happiness.
Abstract:
Self-management is person’s ability to influence one’s own behaviour at workplace, in several other platforms and in life in order to improve one’s performance. In daily life we all run into situations that impact our mental and emotional health. Some such incidents being insignificant are easily transpired leaving us calm mentally and unruffled emotionally. There are however, situations that precipitate excessive stress and anxiety on our mental and emotional well-being. If we are emotionally strong we collect ourselves, are able to manage our actions well in public and bounce back. Such persons emerge as leaders and show high productivity even under adverse situations. At the same time there are people who are unable to take this kind of stress and easily mess up their relations in workplace and in life, and also develop health issues.
It is proven scientifically that fitness to manage stress is proportionately related to one’s Emotional Intelligence (EI), the ability to recognize, understand and manage one’s emotions. If we have a low EI, we will allow stress to speak and will be ruled by negative emotions. In recent times there is an increased emphasis on creating awareness amongst people about ways to cope with stress and anxiety. Several self-management techniques to enhance the EI have emerged and people are willingly drawn to such therapies. Meditation which calms not only our body but also our mind and soul is a promising and widely adopted technique. In meditation we are at total peace with ourselves and attain power of concentration. If meditation is practiced with a regulated breathing pattern, it becomes a powerful tool against stress. Chanting mantra is type of meditation where mind chattering is minimized and internal system purified through deep breathing.
Marycon Anne C Boston
Psychology Instructor, University of the Philippines
Title: Resist the urge: exploring the sources of abstinence self-efficacy of drug rehabilitation residents in Iloilo
Biography:
Marycon Anne just graduated from the University of the Philippines with a double degree in BA (Psychology-Management). Currently, she is a Psychology Instructor in the same university, handling subjects such as Qualitative Methods, Cognitive Psychology and Child Psychology. In her undergraduate years, she conducted studies on the life of prisoners in the facilities of Bureau of Jail Management and Penology. Her research stated above was a life-changing endeavor for the young student. Having to interact with those kinds of people made her more passionate in the field of incarceration and rehabilitation. The research is very timely and essential in fully understanding the struggles of drug addicts and for the country to stop its mandate of extrajudicial killings. If God permits, Marycon wants to pursue graduate studies in Clinical Psychology and focus on traumatic counselling and substance abuse rehabilitation.
Abstract:
Statement of the Problem: Philippines is now facing a huge problem in eradicating drug addiction and trade. There were an alarming number of drug users who surrendered to the government’s mandate of War on Drugs. Despite the urgency for treatment, surrenderers cannot avail these services because of the lacking facilities and professionals which can aid in their rehabilitation. Another problem is the question on what kinds of interventions the patients should undergo to achieve long-term substance abstinence. Self-efficacy is an important indicator of future performance or outcome in any field. Integrating Albert Bandura’s Self-Efficacy Theory in substance abuse, the current study seeks to identify the factors which contribute to abstinence self-efficacy of illicit drug users.
Methodology: In evaluating the sources of efficacy: history of drug use, social models, verbal persuasion and emotional state, drug surrenderers (n =139) undergoing rehabilitation in the province of Iloilo were administered scales and questionnaires. A Pearson product moment correlation was utilized to examine the predictive relationship of the sources and abstinence efficacy. Interviews and focused group discussions were also conducted to provide an in-depth understanding of the relationship of the variables.
Findings: Results of the quantitative analysis indicated that the four hypothesized sources do not significantly correlate with drug abstinence efficacy. Cognitive appraisal through assessing the difficulty of abstinence, perceived personal control, and the varying interpretation of experiences served as barriers in raising one’s confidence to resist drug use. The physical cravings elicited by drug use also prevented the residents to be positively influenced by external factors. Conclusion and Significance: In order to end addiction, people should develop inner control and willingness to abstain. Thus, by capitalizing on cognitive resources through increasing the number of psychologists and creating person-centered interventions, the treatment facilities can better lead the residents to successful recovery and lifetime abstinence.
Kyung-Shin LEE
Environmental Health Center, Seoul National University College of Medicine, Republic of Korea
Title: Urinary phthalate metabolites concentrations and symptoms of depression in an elderly population
Biography:
Kyung-Shin Lee is a major in public health and is interested in environmental and health effects. Recently, she published the association phthalate exposure and the symptoms of depression in an elderly population. Now, she has analyzed the association between climate change and health effect among vulnerable people.
Abstract:
Background: Animal studies have reported an association between phthalates and depression, although there is limited evidence from epidemiological studies. We investigated the association between phthalate exposure and symptoms of depression in an elderly population.
Methods: Repeated measures surveys up to three times were conducted during the study period (2012-2014) in the 535 elderly subjects. We measured the following urinary phthalate metabolite levels: mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-(2-ethyl-5-carboxypentyl) phthalate (MECPP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). MEHHP, MEOHP, and MECPP are metabolites of diethylhexyl phthalates (DEHP). MnBP and MBzP are metabolites of dibutyl phthalate and butyl benzyl phthalate, respectively. The phthalate metabolite concentrations were evaluated to identify associations with the symptoms of depression using the Korean version of the Geriatric Depression Scale-Short Form (SGDS-K). After factor analysis of the components of SGDS-K, we evaluated the association between phthalate exposure and SGDS-K subgroups to determine which symptoms of depression were affected by phthalate exposure.
Results: Concentrations of DEHP metabolites were positively associated with the risk of depressive symptoms in the elderly population (Odds ratio (95% confidence interval); 1.92 (1.17-3.13) for sum of three DEHP metabolites), while we found no significant association between depressive symptoms and either MnBP or MBzP. When we evaluated the associations between phthalate metabolite concentrations and the SDGS-K subgroup, we found that affective and spiritual symptoms were significantly associated with DEHP metabolite concentrations.
Conclusions: Our study suggests that DEHP exposure is associated with depressive symptoms, particularly, the affective and spiritual symptoms, among the elderly population.
Rajeevan Moothal
Sri Nithyananda Yogashrama, India
Title: The role of yoga in anxiety treatment and cure: A case study among some students in Kerala, India and the improvement of their life
Biography:
Rajeevan Moothal is Senior Yoga Teacher who has his expertise in evaluation and passion in improving the health and wellbeing. He has treated various people suffering from anxiety, depression, high blood pressure, diabetes, etc using varius yoga techniques such as yogasana, pranayama, meditation, suryanamaskar, etc. He is a an ayurvedic dietician and nutritionist also. His methods of treatment includes yoga and diet. His methods of life skill development has improved the life of many students and adults in India.
Abstract:
Statement of the Problem: Students between the age of 10 and 18 are always at the risk of anxiety and depression, if the society do not treat them as they needed. As, many of the students are hyperactive, the response or treatment that they get from their elders are always very negative and non cooperative. In this context many students either fall to anxiety or depression, when as their mind-body interventions become less active. The purpose of this study is to help the students to improve their mind-body interventions active and cure the stress related conditions. I have introduced Yoga as a method to treat the common anxiety and depression behavioural problems in these students. The study and treatment has completed for a span of two years, changing the students completely to a new way of life.
Methodology & Theoretical Orientation: The theoretical study and practice of Yama and Niyama of Ashtanga Yoga have recommended for all students for the build up of strong character base. Various yoga techniques such as Slow Surya namaskar for anxiety problems and fast Surya namaskar for depression problems were prescribed. Similary Nadisuddhi Pranayama prescribed for both anxiety and depression cases equally important. Followed by 15 minutes Meditation prescribed for stabilizing the mind.
Findings: Students with anxiety problems have improved their concentration and contentment within themselves. Students with depression have improved their level of concentration and enthusiasm and joyfulness in their life. Conclusion & Significance: Nadi Shuddhi Pranayama have mainly influenced in building up the concentration and peacefulness among the students. Suryanamaskar helped in improving the emotional balance of the students and their mathematical capacities. Recommendations are made for treatment centers to make yoga techniques as an important method for the treatment of anxiety and depression.
Joseph Rosado
Medical Director, Medical Cannabis Clinic, USA
Title: A Clinical Case Study of a 45 y/o female suffering with PTSD, Bipolar D/O, depression, anxiety and chronic pain syndrome taking 42-58 pills per day as weaned off of all medications using Medical Cannabis
Biography:
Abstract:
Posttraumatic stress disorder (PTSD) is a prevalent, chronic, and disabling anxiety disorder that may develop following exposure to a traumatic event.
Although the use of Medical Cannabis for the treatment of physical and psychological disorders is controversial, medical marijuana is currently legal in Canada, 30 states in the United States and a handful of countries in South America.
Studies published in Molecular Psychiatry and Science Daily showed that treatment using particular compounds found in marijuana may benefit those with PTSD, and that “plant-derived cannabinoids [psychoactive chemicals] such as marijuana may possess some benefits in individuals with PTSD by helping relieve haunting nightmares and other symptoms of PTSD” and As a result of taking medical marijuana, participants reported a decrease in re-experiencing the trauma, less avoidance of situations that reminded them of the trauma, and a decline in hyper-arousal, respectively.
There’s also convincing evidence from multiple studies for reduced endocannabinoid availability in PTSD, i.e., reduced levels of the endocannabinoid anandamide and compensatory increase of CB1 receptor availability in PTSD, and an association between increased CB1 receptor availability in the amygdala and abnormal threat processing, as well as increased severity of hyperarousal, but not dysphoric symptomatology, in trauma survivors.
Other studies suggest that Medical Cannabis therapy, as an adjunct to a traditional analgesic therapy, can be an efficacious tool to make more effective the management of chronic pain and its consequences on functional and psychological dimensions.
The patient in this case study had been treated for over 20 years with multiple opiates, SSRIs, SNRIs, typical and atypical antipsychotics, antiepileptics, etc. to manage her conditions; I will demonstrate how in less than three months, she was off of all of the pharmacological treatments and solely using Medical Cannabis is having a quality of life she had not experienced since before her adolescence.
N. Nkengurutse
Psychiatric Clinic, Republic of Burundi
Title: Mental Health, recovery and resilience in Burundi: What happens in under-served communities
Biography:
Abstract:
Background and purpose: The resilience approach is in keeping with the World Health Organization's conceptualization of mental health as a positive state of psychological well-being going beyond the absence of disease (World Health Organization, 2005).
Accumulating evidence indicates the beneficial effects of a psychosocial support on general well-being in patients with mental health impairments. Less evidence is available on benefits of social-economic reinsertion in mental health resilience. This study examined the association between social rehabilitation and recovery status for one year in persons with mental illness.
Methods: A longitudinal study using information from mental health database within Psychiatric clinic included 120 inpatients aged between 15-55 in 2017. We Collected data during stay and approximately 1 year after they were discharged.
WHODAS tool was used to gather information.
Results: The mean age of sample was 22.4. Patients were women(61.5%), men(48.5%); married (43%); rural (89, 4%), under-educated (75%); refugees (93%); from large families(74%); without land (83%), job (87%) or access to health system (47%).They used traditional (92%) or faith care (35%). Screening was made by family (50%), neighbors (35%), community workers (10%) or care providers (5%).
GP diagnosed 100% of people: with Depression (57%), Psychotic features (20%), Bipolar disorders (13%), Schizophrenia (8 %). 65 % was trauma patients. Average length of stay was 20.1 days.
After one year: Home visits (12%), Psychological support (25%), medical treatment (14%) was provided. Stigmatization (60%) and poor economic reinsertion (90%) undermined improvement. Full recovery (30%) and relapse (42%) of patients were noticed 12 months later.
Conclusion and implications: This study shows how people struggle to recover from a mental illness despite challenge of access to medical services and poor social reinsertion which jeopardizes resilience.
Iftikhar Ahmad Saifi
Sports & Physical Therapy Doctor, United Arab Emirates
Title: Wet Cupping Therapy (Hijamah)
Biography:
Dr. Iftikhar Ahmad Saifi had obtained his Bachelor’s degree in Unani Medicine and Surgery (BUMS) from India. He is a registered Unani Medicine Doctor, AYUSH, Ministry of Health (MOH), India. Dr. Ahmed is also a Doctor of Naturopathic Medicine (ND), in USA. He is into American Naturopathic Medical Certification & Accreditation Board, USA. He also practiced Clinical Naturopathic medicine in Los Angeles, USA for good 10 years. Dr. Ahmed Saifi is a Licensed TCAM Doctor at Ministry of Health (MOH), and Dubai Health Authority (DHA) in UAE. He is a Member, an Examination Board, and Department of Licensure for TCAM, Ministry of Health (MOH), UAE for more than 8 years. He was awarded with the highly prestigious “Ibn Sina (Avicenna) International Award for Excellence in Unani (Greek) Medicine”, India (2018).
Abstract:
Wet cupping is a form of bloodletting that involves first making superficial incisions on the skin, then applying the suction cups to suck out small amount of blood. It is the application performed to draw out stagnant, congested blood and Vital Force, as well as other stagnant or morbid humors.
Cupping therapy is an incredibly ancient and universal practice that spans both East and West. In the East, the Chinese have been practicing the art of cupping for at least three thousand years. Cupping is applied to the acupuncture points to relieve the stagnation of Qi and blood, both locally and in the organ(s) activated by the point.
Traditional healers have long recognized the association between pain and conditions of congestion, stagnation and blockage. An old Chinese medical maxim states: Where there's stagnation, there will be pain. Remove the stagnation, and you remove the pain.
Not only pain, but the vast majority of all illness and disease including a number of psychiatric conditions come from stagnation, congestion and blockage - of energy, like the Vital Force, or of vital fluids or humors, like blood, phlegm or lymph. The suction applied by cupping sucks out and breaks up that congestion, stagnation, or blockage, restoring a free flow to the vital energies and humors of the organism.
After falling out of favor with medicine in the modern era, cupping therapy is enjoying resurgence in popularity, promoted by acupuncturists, Unani (Greek) medicine physicians and other holistic healthcare practitioners. New and exciting variations on this ancient technique, like cupping massage, are also being developed.
One secret of cupping's perennial popularity is its great ability to promote a state of deep pleasure and profound relaxation. Hopefully, cupping is here to stay.
- Child and Adolescent Mood Disorders | Schizophrenia and Bipolar Disorders | Clinical Psychiatry | Neuropsychiatry | Psychology | Mindfulness for Mental Well-being
Session Introduction
M.R.Kotwal
Sikkim India
Title: Scientific yogic meditation an ancient technique for de- stressing stress
Biography:
Abstract:
Introduction: We live in an era of constant information and almost infinite possibilities. Multitasking leaves us stressed. Daily meditation physically transforms the cerebral cortex. The most unexpected and comforting recent research confirm that the human brain retains an astonishing degree of plasticity and capacity for learning throughout life. Our mental performance, despite a few glitches with short-term memory, does not peak until mid life, when the white matter in the loftiest parts of the brain is thickest.
AIM & Methods: To evaluate efficacy of a self-learning de-stressing technique Swastya Sukha Satyam Shivam Sundram. Randomly assigned 60 students meditation group from 114 students practiced meditation for 12 weeks and rest formed control group. Five-step relaxation meditation is based on ancient wisdom of over 2500 years with modern scientific concept. Five-step relaxation meditation practiced for 20 minutes 5 days weekly was taught to meditation group, while control group did not practice.
Results: A questionnaire analyzed confirmed validity, reliability and reproducibility. Three factors (Psyche, physical and life adjustment, Happiness, and moodiness) in the group that meditated two times a week for 12 weeks optimally showed statistically significant ( p< 0.0001) results..
Conclusion: Preliminary evaluation of an innovative Relaxation Meditation practice. The technique Could be used in many medical situations which generate undue psychological stress and anxiety, to enhance well-being. The technique could promote health and prevent stress disorders. DVD movie presentation of the technique would be made. The technique is fully explained and is most simple exercise that can induce a nustress.
Biography:
Abstract:
Given a second chance at this life, he has found his purpose in life: helping to heal after experiencing it all. He will tell “what works" and by influencing the audience members to practice strongly the must "do's" that definitely change lives, opening minds of all. Skipping the bloodshed as Angel has already faced, beating the suffering of not being able to walk, talk, or breath, the judgements from all, and coming out on top becoming the most positive, powerful person. Now with the strongest mind-set he is set to share his new found glory in life having the best experiences. Audience members can live the best life by practicing simple things that Angel speaks about; such as meditation, and Loving yourself for "just a few examples", things he know lives by today, and every day!! Learning from a master these powerful techniques, Angel now lives by these today in which he strongly; no longer just “believes”... He “KNOW’S” are life changers. He talks about how to: beat mental health, the Importance to protect the most important part of our body “our brains", “Loving ourselves” = which is #1, and to overcome all our problems. Has been seen speaking at all sorts of different events around the world touching hearts of many connecting all to a higher source of power, identifying with something greater than the material world. Healing through mindfulness assists everyone to gain such constant manifestations, all your desires such magical results in life making life so easy! Your group will now know how to become spiritually aligned, discovering the essence of your being, the deepest values by which we live by. Continue on their journey of life to become more aware, healthier, stronger, wiser, enlightened and becoming more aligned.
Jonghun Lee
Catholic University of Daegu School of Medicine, Daegu, Republic of Korea
Title: Factors associated with smoking frequency and suicidal attempt in Korean adolescent smokers
Biography:
Dr. Jonghun Lee, Medical Doctor (Ph.D.), is a psychiatrist, specializing in mood disorder and adolescent psychiatry. With a completion of psychiatry residency at Chung-Ang University. Now Dr. Lee is a head professor of psychiatry in Catholic University of Daegu School of Medicine. Dr. Lee got the “Commendation from the Minister of Health and Welfare” in 2016
Abstract:
Objectives: Smoking is known to increase the number of physical and mental illnesses and suicide attempts, and is often initiated during adolescence. Among adolescents, unlike in adults, the proportion of daily smoking tends to increase with age, and does not return to the previous level. Therefore, we examined the factors associated with smoking frequency in a nationwide sample of Korean adolescents to help prevent the progression of smoking.
Methods: Among 127,804 adolescents who participated in the 2016 and 2017 Korean Youth Risk Behavior Web-Based Survey, data from 7781 adolescents who replied that they currently smoked were analyzed. According to the frequency of cigarette smoking, participants were classified into daily and non-daily smokers. Participants’ socio-demographic characteristics, smoking behavior, and psychological problems including perceived stress, depressive mood, and suicidality were assessed.
Results: Mean age of current smokers was 16.15 ± 0.04 years. There were 3627(47.4%) daily smokers and 4154(52.6%) non-daily smokers. Low parental educational level, and early smoking experience were positively associated with daily smoking. High academic achievement, and high socio-economic status were negatively associated with daily smoking. Daily smoking was positively associated with lower happiness, lower sleep satisfaction and severe stress during the past 12 months. Factors affecting suicide attempts of smokers were sex, residential type, socioeconomic status, and early smoking experience.
Conclusions: The results indicated that being male, older age, socially disadvantaged families, and early smoking experience influenced daily smoking among Korean adolescents. Daily smoking was associated with psychological problems including lower happiness, lower sleep satisfaction, and severe stress. Early intervention for smoking cessation in this high-risk group may contribute to prevention of harmful effects of smoking.
Biography:
Dr Asghar is a UK trained Clinical Psychologist currently working in Qatar. She graduated with a BSc (Honours) in Psychology in 2003 and a Doctorate in Clinical Psychology in 2008, both from the University of Glasgow. She attained Chartered status from the British Psychological Society and was awarded the title of Associate Fellow of the British Psychological Society (AFBPsS) on the 1st of October 2015 in recognition of her experience and contribution to the field of psychology since she qualified.
Dr Asghar is highly experienced in providing evidence-based psychotherapy and has worked across a range of services in the UK with children, young people and families with complex needs. These include: outpatient Child and Adolescent Mental Health Services (CAMHS), inpatient CAMHS, Looked After and Accommodated Children (LAAC), Liaison Psychiatry and Pediatric Clinical Psychology and Paediatric Neuropsychology. Dr Asghar also maintained private practice in the UK providing specialist medico-legal assessments.
Abstract:
Michał Skalski
Department of Psychiatry, Medical University of Warsaw, Poland
Title: Pharmaco-electroencephalography-based assessment of antidepressant drug efficacy
Biography:
Abstract:
This study was partially financed from a grant from the National Science Center [Narodowe Centrum Nauki] (NCN2012/07/B/NZ7/04375) and statutory founds from Medical University of Warsaw. Pharmaco-encephalography (pharmaco-EEG) assesses the effects of drugs on brain bioelectrical activity.
Specific EEG patterns have been shown to be specific for individual classes of drugs (Herrmann and Schearer, 1986; Skubis, 1991; Szelenberger, 1990; Skalski et al., 1995):
- Anxiolytic drug effects: increased beta (beta 1) activity, decreased alpha power, and increased delta and theta power.
- Antipsychotic drug effects: increased power of theta and delta activity, decreased beta 1 power, increased slow-wave activity and reduced alpha power.
- Antidepressant drug effects – slowed alpha frequency, increased theta and fast beta (beta 2) activity.
- Psychostimulant (amphetamine-like) drug effects – decreased delta and theta power, increased alpha and beta power.
- Nootropic drug effects – decreased delta and theta power, increased alpha activity.
- Lithium effects – increased delta and theta power, slowed alpha activity.
We analyzed pharmaco-EEG profiles in 91 patients hospitalized at our Department of Psychiatry (Medical University of Warsaw) for major depression over an 8-week period. Thirty-nine (39) of those patients received tricyclic antidepressants (TCA), 35 received fluoxetine, and 17 received fluoxetine augmented with magnesium ions. All patients were evaluated with the Hamilton Depression Rating Scale (HDRS) and had their serum drug levels monitored.
Our study demonstrated a relationship between achieving remission (HDRS≤6 at week 8 of treatment) and obtaining a positive pharmaco-EEG profile 6 hours after administering the first dose in the group receiving fluoxetine treatment augmented with magnesium ions (p = 0.0091).
Maria Radziwoń-Zaleska
Department of Psychiatry, Medical University of Warsaw, Poland
Title: Therapeutic drug monitoring of magnesium–augmented therapy
Biography:
Abstract:
This study was partially financed from a grant from the National Science Center [Narodowe Centrum Nauki] (NCN2012/07/B/NZ7/04375) and statutory founds from Medical University of Warsaw.
Summary:
- Therapeutic drug monitoring (TDM), which uses clinical pharmacokinetic data, helps individualize and optimize medical treatment.
- The aim of this study was to assess the efficacy and safety of antidepressant therapy augmented with magnesium ions.
- The research was conducted in the Department of Psychiatry, Medical University of Warsaw. Thirty-seven patients receiving fluoxetine therapy due to an earlier depressive episode were included in this double-blind study, involving antidepressant treatment with the addition of either magnesium ions or placebo.
- During an 8-week follow-up, the patients’ clinical status was assessed with psychometric scales, their blood fluoxetine and magnesium levels were monitored, and pharmaco-EEG was conducted. The obtained results were analyzed.
- The magnesium and placebo groups demonstrated no significant differences in terms of treatment efficacy or safety at any stages of therapy. Moreover, there were no statistically significant differences in pharmaco-EEG profiles between the two groups.
- Nonetheless, a multivariate statistical analysis of the entire study group showed lower baseline Hamilton Depression Rating Scale (HDRS) scores, female gender, smoking, and treatment augmentation with magnesium to be factors increasing the odds of effective treatment. The factors that increased the odds of remission were: lower baseline HDRS scores, shorter history of disease, the presence of antidepressant-induced changes in the pharmaco-EEG profile at 6 hours after treatment, and the fact of receiving treatment augmented with magnesium ions.
Biography:
Abstract:
The neurobiological underpinnings of Depression have been now widely recognized and researched. Studies have shown that multiple brain mechanisms play a major role in the pathology, primality the limbic and prefrontal networks. It is the disruption of the control of prefrontal over the hyperactive limbic regions that causes excessive ruminations and decreased ability to think clearly. Cognitive control involves working memory, response inhibition and mental flexibility. We propose that training on these areas may help recover these functions and rewire the brain for cognitive control back to the frontal. We present the findings of 10 cases seen for cognitive control training. All the cases were diagnosed with Depression and scored 17 or above on BDI prior to intervention. They were also assessed on BAI, Metacognitive questionnaire, cognitive emotion regulation questionnaire and quality of life and satisfaction questionnaire along with neuropsychological measures before and after the 18-session intervention. The training involved tasks which focused on Cognitive Control functions of cold (purely cognitive) and hot (cognitive-emotional) networks. The results indicate that training these networks may be beneficial in uplifting the mood while also improving cognitions. The improvement is also reflected in better emotional regulation and reduced negative metacognitions.
Biography:
Dao Duy Van has completed his pharmacist bachelor degree at the age of 23 years from Hanoi University of pharmacy. I am Van, a pharmacist, personal development lover, meditation practitioners, and lifelong learner, all combine to find the answer for human problems.
The school with teachers: books, internet, video, forum, every people; Van's teachers is also the well-known speakers, authors: Stephen Covey, Jim Rohn, Brian Tracy, Peter Drucker, John. C Maxwell, Daniel Pink, Jim Collin, Jame Allens, Napoleon Hill, Dale Carnegie, Seth Godin, Micheal Porter, Darren Hardy, Richard Branson, Tony Robbin, Daniel Goleman, Malcolm Gladwell, Wayne Dyer, Hanh Thich Nhat, Richard Mathieu, and many successful authors. Most of the authors value the attitude, principles, virtue, brain, and mind to the success but there are little support evidence and a lot of debating in society.
Abstract:
They lack social skills, they cannot talk: language is the product of living environment - as your native language and my native language, we speak it naturally without thinking at all. We are not born with our native language, so I doubt their connection with their living environment and/or the state of mind that they can not/don't want to learn. You can test them with Aesop fables(they do not understand), pretending game - they do not understand, interacting, communicating or persuading.
They are in the low level of this. For official test: you can test them with EQ test, and Aesop stories, metaphors. All these low-level vital skills make them never feel safe, connection to the environment: it makes them stress. Over time, it makes the downward spiral that make them more and more lack of social skills and suffer more stress.
ALL IN ONE, ONE IN ALL:
Dear Neurologist, psychiatrist, sociologist, gastroenterologist, urologist, educators, sleep therapists, cardiologist, language therapists, educators, trainers, teachers: there is no separation in the health of heart, stomach, muscle, cognitive thinking, sleeping, hormone system: all are interdependent and under the state of mind. IT IS THE ADVANTAGES OF EASTERN PHILOSOPHY AND THE BASIC OF EASTERN TRADITIONAL MEDICINE.
PARETO IN HEALTH/MEDICINE
Remember when working with the MIND: irrational mind, the giant brain evolved for millions of years, illogical mind and Placebo effects, Neuro-plasticity, Mirror neurons, self affirmation, self-talk, nocebo effects, T1/2 of all substances, taboos, rituals, religious belief, compound effects, CONDITIONED RESPONSES, and MAGICAL ADAPTABILITY, ILLUSIVE MIND, Self healing/destroying, IRRATIONAL THINKING, Subliminal message, Marketing of luxury brand, and Hysteria: what do we feed the mind of beings everyday?
AND what if all of these lead to negativity or positivity? Maybe Outliers or Failures!
- 5 mins of rapping can affect whole life.
- 5 mins of abusing can make victims fear whole life
- 1 mins of bombing, earthquake, fear, hysterical stress the killing can affect their whole life.
- It creates the conditioned of Fight and Flight that they can not consciously control.
- They rarely joy
- It is said by genes
- So they accept it as gifts
- Or nobles term, not diseases
- Even they take more expensive medication than others.
Read their behaviors, read the body language. In stress state, stress chemicals: adrenalin, noradrenalin, and cortisol will dominate the body. The effect is listed in any medical book, look closer we can see all these effects are available in kids, to some extents, the effects caused by stress chemicals are the best answer for the autistic rainbow. Sorry, they are not happy with the label GIFTED.
REDEFINE OF STRESS
The right definition of stress: Human beings have basic human needs described by Abraham Maslow. Anything threatens of satisfying these needs will lead to Fight and Flight responses. IF people cannot change the situation, threaten, they will be the victims of STRESS AND STRESS HORMONES.